Zhe Zhao
Zhe Zhao — researcher or builder tracked in the Angestrom contributor network.
Papers · 2
Language-Informed Flow Matching for Trend-Guided Structure-Based 3D Molecular Generation
Structure-based drug design (SBDD) requires ligands that satisfy both 3D target affinity and 1D chemical validity. Existing controllable generation methods often rely on task-specific fine-tuning or externally imposed sampling-time guidance, adding cost and potentially conflicting with evolving 3D geometric constraints. We propose LiFT, a language-informed cross-modal framework built on Flow Matching for trend-guided 3D molecular generation across both de novo design and scaffold hopping. LiFT uses a "Sense-Evolve-Assemble" agent to generate target-aware SMILES as intermediate chemical conditi
Recursive Experiential-Working Memory Evolution for Long-Horizon Agent Harnesses
Recursive self-improvement (RSI) remains hard in long-horizon tasks, where growing histories obscure the task state and misalign skill invocation. We introduce Recuris, a recursive Experiential-Working Memory architecture for long-horizon agent harnesses, in which Working Memory tracks task progress and guides skill selection from Experiential Memory, grounding skill use in current needs rather than the full history. This coupling also turns execution into structured evidence that localizes failures to specific memory components. Across tasks, a fixed Meta-Agent turns that evidence into locali