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paperarXivTrust 82 · PrimaryPublished 11h agoLive · 50m ago

Data-Efficient and Interpretable Classification of Circulating Tumor Cell Phenotypes in Microfluidic Devices via Deep Learning

Accurate classification of circulating tumor cell (CTC) phenotypes can provide valuable information for assessing metastatic potential. Label free microfluidic devices provide a hydrodynamic obstacle course that transforms subtle biophysical characteristics of CTCs, including size and deformability, into distinct kinematic trajectories. However, the highly nonlinear fluid structure interactions governing these trajectories make the inverse problem of inferring cellular phenotype from trajectory data analytically intractable. While deep neural networks (DNNs) have emerged as a powerful approach

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