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paperarXivTrust 82 · PrimaryPublished 26d agoLive · 26d ago

M$^3$-Gen: Interpretable Multimodal Generation of Gene Expression Profiles Using Clinical and Imaging Data

Integrating heterogeneous biomedical data, including clinical metadata, histopathology images, and molecular profiles, is crucial for comprehensive disease understanding. However, gene expression data acquisition remains constrained by high costs and privacy concerns, limiting its use in multimodal research and AI-driven applications. We present MultiModal Molecular Generation (M$^3$-Gen), a novel framework for the generation of gene expression profiles by conditioning a Generative Adversarial Network on histopathology images and clinical metadata. M$^3$-Gen learns a unified latent representat

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